Rejuran Microneedling in Hackensack, NJ

April 30, 2026

How Salmon DNA (PDRN) Is Changing Skin Rejuvenation

By Dr. Jijoe Joseph & Dr. Nancy Nguyen | Board-Certified Physicians, Aesura Health

You’ve probably seen “salmon DNA” trending on skincare social media. Behind the catchy name is real regenerative science — and it’s now available right here in Hackensack, NJ.

The ingredient is called PDRN (polydeoxyribonucleotide), a bioactive compound derived from salmon DNA that works at the cellular level to repair your skin, not just cover up damage. At Aesura Health, we use Rejuran Healing Essence, an FDA-approved PDRN formula for topical application — paired with professional microneedling to deliver regenerative benefits deep into the skin.

Let’s walk through what PDRN actually does, what the clinical research shows, and how this treatment fits into a comprehensive skin health strategy.

What Is PDRN and How Does Rejuran Microneedling Work?

PDRN stands for polydeoxyribonucleotide — purified fragments of DNA derived from salmon. Salmon DNA is structurally similar to human DNA, which makes it highly biocompatible. Your body recognizes these DNA fragments and uses them to activate repair processes that naturally slow down as we age.

Rejuran Healing Essence is formulated with c-PDRN (a patented, concentrated form of PDRN) along with hyaluronic acid and amino acids. In the U.S., Rejuran is FDA-approved for topical application, which means the compliant delivery method in clinical practice is through microneedling — not injection.

How Rejuran Microneedling Treatment Works

The process combines two powerful mechanisms:

Microneedling creates thousands of controlled microchannels (0.25–1.5mm deep) in the skin. This triggers your body’s natural wound-healing response, stimulating collagen and elastin production on its own.
Rejuran Healing Essence is applied during the microneedling session. The microchannels dramatically increase absorption, allowing the c-PDRN to penetrate the upper dermis where it activates cellular repair.

Together, you get a dual regenerative effect: your skin is repairing from the microneedling stimulus while simultaneously being fed the building blocks for cellular regeneration through PDRN.

What PDRN Does at the Cellular Level

Activates the A2A adenosine receptor: Triggers a healing cascade that activates cell repair.
Boosts collagen production: Stimulates fibroblasts, increasing collagen synthesis by approximately 25%.
Reduces inflammation: Suppresses inflammatory pathways — especially valuable for UV-damaged or sensitive skin.
Promotes blood vessel growth: Better nutrient delivery means healthier, more radiant skin.
Slows cellular aging: 2025 research shows PDRN preserves SIRT1, a key anti-aging protein, and reduces cellular senescence.

The Latest Data & Research Behind PDRN

PDRN has a strong body of peer-reviewed evidence. Clinical trials have demonstrated significant improvements in wrinkle reduction — including a 61.4% reduction in periorbital wrinkles after 12 weeks in a Phase III trial with 218 patients, with fine lines improving up to 38%.

Research also shows PDRN upregulates genes for collagen (COL1A1), elastin (ELN), and fibrillin (FBN1) — the structural proteins responsible for skin firmness and elasticity. Beyond aesthetics, PDRN accelerates wound healing even in compromised skin and protects cells from UV-induced and oxidative damage.

When PDRN is combined with microneedling, the delivery is enhanced because the microchannels allow the active ingredient to reach the dermal layer where fibroblasts and collagen synthesis occur — making the treatment more effective than either approach alone.

What to Expect During Rejuran Microneedling Treatment at Aesura Health

Here’s how a Rejuran microneedling session works at our practice:

Consultation: One of our board-certified physicians assesses your skin, discusses your goals, and confirms Rejuran microneedling is the right fit.
Numbing: A topical numbing cream is applied for comfort. You’ll wait about 20–30 minutes for it to take effect.
Microneedling + Rejuran application: The microneedling device creates microchannels while Rejuran Healing Essence is applied to the skin. The c-PDRN is absorbed through the channels into the deeper skin layers. The session takes about 30–45 minutes.
Post-treatment: Mild redness and slight swelling are normal and typically resolve within 24–48 hours. Most patients return to normal activities the next day.

The Microneedling Results Timeline

Days 7–10: Initial improvement in hydration and skin texture
Weeks 4–6: Noticeable improvement in tone, smoothness, and fine lines
Weeks 8–12: Peak collagen remodeling and firmness improvement

For optimal results, we recommend 3–4 sessions spaced 3–4 weeks apart, with maintenance treatments every few months. Every protocol is customized to you.

The Aesura Difference: More Than Just Microneedling

What makes this treatment different at Aesura: we don’t treat your skin in isolation. We practice at the intersection of aesthetics, longevity, and regenerative medicine. Skin quality reflects what’s happening inside your body — and we address the whole picture.

Rejuran microneedling pairs naturally with other treatments we offer:

PRP (Platelet-Rich Plasma): Your own growth factors paired with PDRN for a dual regenerative approach.
Sculptra: PDRN repairs skin quality while Sculptra stimulates deeper structural collagen.
Peptide Therapy: Systemic repair from peptides complements the topical cellular regeneration from PDRN.
Red Light Therapy: Enhanced mitochondrial function supports PDRN’s cellular repair mechanisms.
Hormone Optimization: Addressing root causes, such as hormonal imbalance, while directly repairing skin.

Potential Side Effects and Considerations for PDRN Microneedling

Common Side Effects (Temporary)

Redness and mild swelling — normal after microneedling; typically resolves within 24–48 hours
Skin sensitivity — the treated area may feel tight or warm for a day or two
Minor bruising — possible in delicate areas; resolves within a few days
Temporary dryness or flaking — as the skin renews itself in the days following treatment

Who Should Avoid This Treatment

Fish or salmon allergy — PDRN is derived from salmon DNA; always disclose allergies
Active skin infections or open wounds — treatment should be postponed
Pregnancy and breastfeeding — not recommended due to limited safety data
Active autoimmune conditions — discuss with your physician first
Recent isotretinoin (Accutane) use — microneedling is typically avoided for 6 months after completing isotretinoin

A Note on the Research

While the clinical evidence for PDRN is promising, most aesthetic studies have been relatively small in scale. Larger randomized controlled trials are still needed. Results are gradual and cumulative — not overnight. We’ll always give you an honest assessment of what this treatment can and can’t do for your skin.

A Note on Rejuran Injections

You may see some clinics advertising Rejuran as an injectable skin booster. While Rejuran injections are widely used in South Korea and other countries, injectable Rejuran is not currently FDA-approved in the United States. The FDA-approved use of Rejuran in the U.S. is for topical application, which is why we use microneedling as the delivery method.

At Aesura Health, we prioritize both efficacy and regulatory compliance. Microneedling with Rejuran Healing Essence delivers the c-PDRN into the skin effectively while staying within FDA guidelines. As the regulatory landscape evolves, we’ll continue to offer the most effective, compliant options available.

Answers to Your Rejuran Treatment Questions

What is Rejuran microneedling?

Rejuran microneedling combines professional microneedling with Rejuran Healing Essence, a topical formula containing c-PDRN (concentrated polydeoxyribonucleotide) derived from salmon DNA. The microneedling creates microchannels that allow the c-PDRN to penetrate into the dermal layer, where it activates cellular repair, boosts collagen production, and reduces inflammation.

Is Rejuran FDA-approved?

Rejuran Healing Essence is FDA-approved for topical application in the United States. This means the compliant delivery method in clinical settings is through microneedling — not injection. Rejuran injectable treatments, while popular internationally, are not currently FDA-approved in the U.S.

How is Rejuran microneedling different from regular microneedling?

Regular microneedling stimulates collagen through the wound-healing response alone. Rejuran microneedling adds the c-PDRN active ingredient, which provides additional cellular repair signals — activating the A2A adenosine receptor, boosting fibroblast activity, and reducing inflammation. You get the benefits of microneedling plus the regenerative effects of PDRN.

How long do results last?

Results from a Rejuran microneedling series typically last several months. Most patients achieve optimal results with 3–4 sessions spaced 3–4 weeks apart, followed by maintenance treatments every few months. Results are cumulative — each session builds on the previous one.

Is the treatment painful?

Most patients find it very comfortable. A topical numbing cream is applied 20–30 minutes before treatment. You may feel mild pressure during the microneedling, but nothing intense. The session takes about 30–45 minutes total.

Can Rejuran microneedling be combined with other treatments?

Yes — we often recommend combination approaches at Aesura Health. Rejuran microneedling pairs well with PRP, Sculptra, peptide therapy, red light therapy, and hormone optimization. Because it improves overall skin health at the cellular level, it creates a stronger foundation for other treatments.

Who is a good candidate?

Rejuran microneedling works well for patients noticing early signs of aging (fine lines, dullness, loss of elasticity), those with acne scarring, sensitive or reactive skin needing barrier repair, or anyone who values gradual, natural-looking skin improvement. It’s safe for all skin types and tones.

Where can I get Rejuran microneedling in New Jersey?

Aesura Health in Hackensack, NJ, offers Rejuran microneedling as part of our regenerative aesthetics program. Located at The Shops at Riverside, our board-certified physicians customize every protocol. Book a consultation at aesura.janeapp.com.